The role of mast cells is well established in lung diseases associated with chronic inflammation [19] such as COPD [20] and asthma [21] and may contribute to their pathogenesis of bronchial remodeling [22]; (2) a smaller population (13% by IF) of c-KitlowCD45+ were tryptase- and may represent ILC [23], a family of innate immune cells that participate in the regulation of the immune response and tissue inflammation [24]. This evidence concerns the gene CCL27 and chronic obstructive pulmonary disease.