Multiple parameters were tested for possible association with SVR12 in patients with GT3 and advanced liver disease: gender, age, platelet counts, baseline HCVRNA, transaminases values, albumin values, co-morbidities including diabetes, and obesity, fibrosis stage, baseline NS5A-RASs, PNPLA3 and IL28B polymorphisms, treatment history and regimen. The gene discussed is PNPLA3; the disease is obesity due to melanocortin 4 receptor deficiency.