However, the associations between cortisol and obesity appear to be more complex than anticipated.[55] Although it promotes changes in the compensatory mechanism of food intake[7,8,21,50], in the leptin system and satiety control mechanism[[7,8]], cortisol is clearly not the only peripheral trigger of adverse effects, which may explain the controversies in this area. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.