MMP9 and Ehlers-Danlos syndrome, hypermobility type: Furthermore, Colombi and her group proposed a regulatory effect of cadherin on the expression of alpha-smooth muscle actin cytoskeleton through the Wnt/b-catenin pathway, the involvement of avβ3 integrin-ILK-mediated signal transduction and Snail/Slug in the overexpression of matrix metallopeptidase-9, disorganization of alpha-smooth muscle actin cytoskeleton and fibroblast to myofibroblast transition, and subsequently, the pathogenesis of hEDS or hypermobility spectrum disorder.