Finally, the deafness-causing TMC1 Beethoven (Bth) mutation (M418K in hTMC1 or M412K in mTMC1) alters the Ca2+ permeability, single channel conductance and dihydrostreptomycin blockade of the MET channel (Beurg et al., 2015a; Corns et al., 2016; Pan et al., 2013). Here, TMC1 is linked to deafness.