PABPC1 and breast cancer: It neutralizes the positive charge on the lysine side chain, relaxing the chromatin structure and enhancing transcriptional activity.35 Histone acetylation named H3K27Ac was first discovered in yeast36 and recent advancements in DNA sequencing technology have enabled the analysis of histone acetylation distribution patterns through whole genome.37 In this study, we investigated the H3K27ac concentration at the promoter of PABPC1 by analysis of ENCODE database, followed by a serious of experimental verifications including RT‐qPCR, ChIP and Western blots using breast cancer tissues and cells.