TNFSF11 and osteoporosis: Its potential usage in anti‐inflammatory and antioxidant activity was reported before,13, 14 and more specifically, its anti‐inflammatory effect in osteoarthritis and NF‐κB signalling blockage.15 In this study, the effect of tectorigenin on RANKL‐induced NF‐κB activation and osteoclastogenesis was investigated in vitro, plus its anti‐osteoporosis action in an ovariectomized (OVX) mice model.