Onphachanh and colleagues demonstrated that melatonin stimulates PINK1 expression via the MT2/Akt/NF‐κB pathway, which is important for the prevention of neuronal cell injury under high glucose conditions.37 Our previous study also demonstrated that melatonin alleviates cardiac remodelling and dysfunction in DCM.38 However, it is still unclear whether PINK1/PARKIN‐mediated mitophagy is the trigger for diabetic cardiomyopathy and, if so, whether melatonin is capable of alleviating diabetic cardiomyopathy by regulating mitophagy. Here, PRKN is linked to diabetic cardiomyopathy.