The results showed that the mRNA expression of GRP78, which is the targeted gene of ATF6, was increased after expressing full‐length and active ATF6 (1–373) in colon cancer or HEK293T cell lines (Fig. 2A; lanes 3, 6, and 9) (Haze et al., 1999). This evidence concerns the gene HSPA5 and colonic neoplasm.