It has been widely acknowledged that early lymph node metastasis is one of the hallmarks of ICC, which contributes to metastasis of tumor cells and early recurrence.39, 40 Similarly, our results also showed the presence of lymph node metastasis was an independent risk factor of ICC and positively correlated with α‐SMA expression in CAFs. The gene discussed is ACTA1; the disease is intrahepatic cholangiocarcinoma.