CD274 and neoplasm: Furthermore, accumulating evidence suggests that platelets play crucial roles in tumor metastasis and suppressing anti‐tumor immunity, as they facilitate the generation of circulating tumor cells, protect these cells from immune surveillance, and enhance the intravasation/extravasation of circulating tumor cells.23, 32, 33 Therefore, the immunosuppressive effects of tumor PD‐L1 expression and high platelet counts might synergistically promote tumor metastasis.