Three patients with grade IV glioma were also positive in [123I]-VEGF SPECT, while the other five patients with grade II or III glioma (one patient with astrocytoma of grade II, one patient with anaplastic oligoastrocytoma of grade III and one patient with anaplastic ganglioglioma of grade III as well as two patients with oligodendroglioma of grade II) had negative [123I]-VEGF SPECT. The gene discussed is VEGFA; the disease is central nervous system cancer.