Vitamin D treatment has shown some anti-inflammatory and hormone-related molecular changes in PCa.51,53,62,63 In Taiwanese PCa patients, genetic variants, HFE rs9393682, and TUSC-3 rs1378033 were associated with time to progression in localized disease and low risk of advanced PCa for patients undergoing androgen deprivation therapy.62 Furthermore, in vitro studies revealed 1,25-Vitamin D downregulated HFE and when silenced HFE impedes cell proliferation and wound healing. This evidence concerns the gene HFE and posterior cortical atrophy.