METTL14 and leukemia: In SPI1-METTL14-MYB/MYC axis, METTL14, is downregulated by SPI1, exerts an oncogenic role in enhancing leukemia stem/initiating cells self-renewal and repressing myeloid differentiation by regulating MYB and MYC via m6A modification (Weng et al., 2017).