A double-blinded prospective study of 106 patients with mCRC has been performed to compare the KRAS mutation status assessed using tumor tissue via routine gold-standard methods to that assessed using plasma DNA via qPCR-based methods; the resultant specificity and sensitivity for the detection of KRAS point mutations were 98 and 92%, respectively, resulting in 96% concordance (28). Here, KRAS is linked to neoplasm.