For example, when tumor cells exposed to double stresses such as hypoxia and ATP deprivation situation, inducible autophagy can lead to the mitochondrial dysfunction and cell death by HIF-1α-mediated Bcl-2 gene families, such as BNIP3 (Bcl-2 adenovirus E1a nineteen kilodalton interacting protein 3) and BNIP3L (Bcl-2 adenovirus E1a nineteen kilodalton interacting protein 3-like)17–19. The gene discussed is BCL2; the disease is neoplasm.