Our previous studies showed that utilizing the POMC gene carrying by adenovirus is efficient way for Lewis lung carcinoma and melanoma suppression in vivo, we then characterized that POMC-derived peptide α-MSH not only inhibits the colony-forming capacity and invasion of melanoma cells24–26 but also retards the tube formation and migration in endothelial cells27,28. The gene discussed is POMC; the disease is Carcinoma, Lewis Lung.