Although more than half of pNETs have biallelic loss of MEN1, the overall frequency of somatic SNVs, indels, and structural DNA variants was low, with small numbers of tumors carrying tumor suppressor variants in ATRX, DAXX, VHL, PTEN, YY1, and PAX6. These variants generally accord with those previously observed in pNETs.9,12,28. This evidence concerns the gene PTEN and neoplasm.