Although we have prioritized functional instead of molecular approaches in this study, our data importantly show that 12-week intake of an isocaloric moderately high-protein diet consistently restored high-sucrose-induced central adiposity and obesity in addition to the attenuation of other important metabolic outcomes, such as improvement of glucolipid homeostasis associated to increased insulin sensitivity and reversal of hepatic steatosis. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.