For instance, FoxO3a overexpression induces apoptosis in a human leukemia T cell line (Brunet et al., 1999), murine CTLL-2 T cell line (Stahl et al., 2002), murine pre-B cell line Ba/F3 (Dijkers et al., 2002), murine peritoneal macrophages (Senokuchi et al., 2008) and BCG-infected macrophages (Haoues et al., 2014). This evidence concerns the gene FOXO3 and leukemia.