HIF-1α plays a critical role in the glycolytic switch to increase glucose utilization in hypoxic tumor cells by upregulating the expression of glucose transporters and glycolytic enzymes, such as glucose transporters 1 and 3 (GLUT1 and GLUT3), pyruvate dehydrogenase, lactate dehydrogenase A (LDHA), phosphoglycerate kinase 1, and hexokinases 1 (HK1) (78). This evidence concerns the gene HK1 and neoplasm.