In the study from Marasco’s group, human anti-CAIX mAbs not only inhibited CAIX enzymatic activity but also promoted immune-mediated killing of RCC by NK cell-mediated antibody-dependent cell-mediated cytotoxicity, complement-dependent cytotoxicity, and macrophage-mediated antibody-dependent cell-mediated cytotoxicity. Here, CA9 is linked to renal cell adenocarcinoma.