Hypoxia has been shown to induce the production of stromal cell-derived factor 1α (SDF1α) by hypoxic tumor cells, which binds to C-X-C chemokine receptor type, IL-8, and IL-6, and directly regulates the function and differentiation of MDSCs within the tumor microenvironment (30, 31). Here, CXCL8 is linked to neoplasm.