VIM and neoplasm: Notably, hypoxic tumor microenvironment was correlated to a high expression of genes that promote epithelial–mesenchymal transition (EMT), including inhibitor of differentiation 2, snail 1 and 2 (SNAI1 and SNAI2), transcription factor 3, transforming growth factor alpha, twist transcription factor (TWIST), vimentin (VIM), and zinc finger E-box-binding homeobox 1 and 2 (ZEB1 and ZEB2) (18–22).