P2RY2 and ganglioneuroma: As shown in Figure 6, P2Y2R deficiency of the donor (P2Y2R−/− = > wt) displayed a significant decrease in all cardinal features of GN, as evidenced by reduced proteinuria, and reduced “damage in histology.” In contrast, P2Y2R−/− animals reconstituted with WT hematopoietic system (recipient) (wt = > P2Y2R−/−) showed only a slight reduction in histological scores compared to WT animals.