These genes were associated with many BPs, including cell proliferation, signal transduction, transcription, Wnt signaling pathway (i.e., BCL9L, FZD6, LRP6, ATP6V0C, BCL9, and PYGO2), vasculogenesis (i.e., ENG and TGFBR2), bone resorption (i.e., TCIRG1), negative regulation of bone mineralization (i.e., SRGN), osteoblast differentiation (i.e., LGR4), and osteoblast development (i.e., LRP5). The gene discussed is FZD6; the disease is Bartsocas-Papas syndrome 1.