The functional analysis of the above-mentioned highly connected modules revealed that the modulated lncRNAs targeted genes involved in BPs that play a pivotal role in the PsA pathogenesis such as, for example, immune response (including B and T cell activation) inflammatory response, TNF, Wnt and type I interferon-mediated signaling, bone resorption, bone mineralization, and glyco-lipid metabolic process (see Results), thus indicating that the selected lncRNAs regulated the three major aspects of the disease, including skin involvement, osteo-articular features, and metabolic syndrome. Here, TNF is linked to metabolic syndrome.