Importantly, there was no significant difference between activated FOXP3+ and activated FOXP3− cells and between resting FOXP3+ and resting FOXP3− cells (Figure 8D), indicating that in the tumor microenvironment, Treg cells are as activated as non-Treg CD4+ T cells, which may be enriched with Teff. The gene discussed is CD4; the disease is neoplasm.