PSD patients compared to non-PSD had higher serum leptin levels at discharge (43.4 (23.4–60.2) vs. 6.4 (3.7–16.8) ng/ml, P < 0.001) and at 1 month after stroke (46.2 (34.0–117.7) vs 6.4 (3.4–12.2) ng/ml, P < 0.001). Here, LEP is linked to stroke disorder.