Tang et al. found that elevated serum concentrations of high-sensitivity C-reactive protein (Hs-CRP) in the acute stroke phase independently predisposed to PSD occurrence at 6 months after its onset (OR:1.3, 95% CI:1.2–1.5, and AUC value of 0.765, 95% CI:0.701–0.983) (59). The gene discussed is CRP; the disease is Stroke.