Our work also previously found that improvements in fasting glucose, 2-h OGTT glucose, or insulin sensitivity were equal in obese individuals with prediabetes randomized to 12-weeks of exercise training (60 min/day at 65% VO2max, 5 days/wk) either with or without 500 kcal/day deficit-induced weight loss (Solomon et al., 2008, 2009). Here, INS is linked to prediabetes syndrome.