NFKB1 and pulmonary arterial hypertension: Kimura et al. (2009) examined the role of NF-κB in PAH, as well as the potential for NP-based therapeutics targeting NF-κB as a treatment strategy. An NF-κB decoy oligodeoxynucleotide meant to inhibit binding of NF-κB to the promoter region was encapsulated within poly(ethylene glycol)-block-lactide/glycolide (PEG-PLGA) polymer micelles.