The harmful production like LPS, released by pathogen bacteria could induce immunological disorders, such as infiltrating and activating macrophage, inducing excessive effector T cells and recruiting neutrophils, resulting in overproduction of many pro-inflammatory cytokines (i.e., IFN-γ, IL-1β, IL-18, IL-6), which exacerbate colitis to a great extent(Bouma and Strober, 2003; Sartor, 2006). This evidence concerns the gene IL18 and colitis.