In contrast, expression of CD4+/IL-10+ (p < 0.001), CD4+/TGF-β+ (p < 0.001), CD4+/IFN-γ+ (p < 0.05) was significantly increased by Fasudil combined with BMSCs, suggesting greater potency of the combination treatment, which appears to prevent the development of AD pathology and its progression by regulating the CD4+ T-cell proliferation and cytokine release. Here, CD4 is linked to Alzheimer disease.