IGFBP2 and Alzheimer disease: Previous studies on AD-associated changes in CSF IGFBP-2 are conflicting; some studies demonstrate elevated levels of CSF IGFBP-2 in AD relative to age-matched controls (Salehi et al., 2008; Hertze et al., 2014), while others report similar findings to our study with no significant difference in CSF IGFBP-2 levels by diagnosis (Åberg et al., 2015; Lane et al., 2017).