Within subgroups, the association between CSF t-tau and IGFBP-2 was significant after correction for multiple testing in CN only (β = 0.58 ± 0.16, p = 2.44×10-4), with MCI (β = 0.54 ± 0.23, p = 0.02) and AD (β = 0.79 ± 0.40, p = 0.05) having p-values above p = 0.017 (Supplementary Table 1). This evidence concerns the gene IGFBP2 and Alzheimer disease.