Comprehensive characterization of the 36 patient UM HNSCC cohort has allowed our group to define important genetic and epigenetic characteristics of HNSCC especially for HPV-associated tumors, resulting in several novel findings: i) two subtypes of HPV+ HNSCC were identified with distinct transcriptional profiles, which were associated with HPV characteristics, specific CNAs, PIK3CA mutations and pathway signatures16; ii) HPV integration in HNSCC was associated with worse survival outcomes, weakened immune response signatures and suggested novel candidate drivers7. This evidence concerns the gene PIK3CA and head and neck squamous cell carcinoma.