FANCA and cancer: Of the 21 germline variants found for FA genes, 2 were not documented in dbSNP database (potentially novel variants) and 3 were annotated as cancer-related by COSMIC database; five were predicted to be benign, 1 in FANCA was likely pathogenic, 5 conflicting or uncertain pathogenicity, and 7 benign/likely benign according to ClinVar clinical significance22 (Supplementary Table S3).