TMEM38B and chronic obstructive pulmonary disease: Among those loci which did not directly replicate for PFTs in the UK BiLEVE or UK Biobank datasets, the lead variants in an additional two European or multiethnic loci were significantly associated in the ICGC Consortium with COPD, which was defined using PFT measures27: TMEM38B/ZNF462 and NCOR2/SCARB1.