Maxfield et al. examined serum POSTN levels in CRSwNP, CRSsNP, healthy subjects, and subjects who underwent endoscopic nasal surgery for conditions other than CRS45, and average serum POSTN levels were higher in CRSwNP with asthma than without, but it did not reach the statistical significance45. The gene discussed is POSTN; the disease is chronic rhinosinusitis without nasal polyps.