In the control group, POSTN deposition was observed only in the subepithelial layer, and the superficial type was observed more in CRSwNP from patients with a less severe phenotype than those with a more severe phenotype, and a significant difference in POSTN staining patterns was observed between the non-ECRS and severe ECRS subtypes (corrected P = 0.037). The gene discussed is POSTN; the disease is chronic rhinosinusitis with nasal polyps.