In view of that EP has a raised expression in the brains of AD patients28 and Tg mice with neuronal overexpression of a mutant human form of APP (Tg mAPP, APPSwInd, J-20 line) driven by the platelet-derived growth factor β-chain promoter at 9–10 months of age (Supplementary Fig. 1a, b), we sought to develop a model system in which neuronal expression of EP would be exaggerated so that consequences of EP-dependent signaling in Aβ-rich environment could be established. Here, APP is linked to Alzheimer disease.