SH3GL2 and Alzheimer disease: Notably, Aβ levels, including Aβ40 and Aβ42, were significantly elevated in the entorhinal cortex (AD-affected regions at very early stages of AD and proceeding hippocampus) of Tg Sh3gl2/mAPP mice as compared with mAPP mice at the age of 5–5.5 months (Fig. 10a, b).