In vitro functional luciferase assays in both neuronal (mouse primary cortical neurons) and non-neuronal (HEK293) cell types demonstrated that in the presence of increasing concentrations of rapamycin, a polymorphic di-nucleotide repeat (DNR) in the 5′-UTR of the DPYSL2B gene dose-dependently decreases allele expression at translation level, suggesting a functional link between this schizophrenia high-risk allele (13 DNRs) and mTOR signaling [236]. The gene discussed is MTOR; the disease is schizophrenia.