SNCA and Huntington disease: Moreover, alpha synuclein immunoreactivity often co-localizes within huntingtin polyglutamine-positive aggregates in brain sections from patients with late-stage Huntington’s disease (HD) patients [91], or even within SOD1-positive inclusions, as revealed by immunohistochemical analysis performed in post-mortem brain and spinal cord from cases of familial ALS [92].