Until now, 11 strumpellin point mutations and one exonic deletion have been identified in a total of 16 families, of which most cause a pure motor form of HSP (Bogucki and Sobczyńska-Tomaszewska, 2017; Jahic et al., 2014; Valdmanis et al., 2007). This evidence concerns the gene WASHC5 and hereditary spastic paraplegia.