RB1 and neoplasm: We find that TEAZ allows for the development of complex, aggressive melanomas driven by expression of oncogenic BRAFV600E in concert with loss of the tumor suppressors tp53 and rb1. These tumors are highly invasive and eventually metastasize to distant locations, unlike previous transgenic zebrafish melanoma models which do not generally metastasize (Patton et al., 2005).