In cultured mPMCs, HG-induced cell morphology changes from a paving stone/cobblestone shape into a fibroblast-like mesenchymal phenotype was partially reversed by Tamoxifen, and effects on E-cadherin and Vimentin levels suggested that Tamoxifen alleviated HG PDF-induced peritoneal fibrosis by reducing EMT [6]. The gene discussed is CDH1; the disease is Peritoneal Fibrosis.