Such loss of nuclear BAP1 is seen in a variety of human cancers, most commonly malignant mesothelioma, uveal melanoma, renal clear cell carcinoma and some cutaneous melanomas (Harbour et al., 2010, Abdel-Rahman et al., 2011, Carbone et al., 2012, Song et al., 2017). The gene discussed is BAP1; the disease is cancer.