Irrespective of stimulation by Wnt proteins, ectopic expression of Ror2 can induce filopodia formation by actin polymerization via coupling of the Ror2-PRD to the actin-binding protein Filamin A. Our in vitro data show that Ror2 induces filopodia formation in PAC2 fibroblasts, myofibroblasts and gastric cancer cells. Here, ROR2 is linked to gastric cancer.