These apparently contradictory results could be explained by cross-regulation of Ror2 and the β-catenin signaling being influenced by tissue heterogeneity. This might occur, for example, during tumor progression (Roarty et al., 2017) when depending on the repertoire of Wnt signaling components present, Ror2-expressing tumor cells regulate the spatial distribution, duration, and amplitude of Wnt/β-catenin signaling within a tumor. This evidence concerns the gene ROR2 and neoplasm.