SLC5A2 and Hyperglycemia: Recently, inhibition of the sodium-glucose co-transporter 2 (SGLT2) in kidneys, a more recent and novel therapeutic approach to lower hyperglycemia, has been shown to slow progression of DKD in preclinical models and clinical studies, either as stand-alone or combination therapy, including DPP-4 inhibitors, GLP-1 receptor antagonist, or ACEi/ARBs [12–14]; however the mechanisms are not entirely known [15–21].