The beneficial effect of EMPA on progression of kidney disease in the EMPA-REG OUTCOME TRIAL and pre-clinical studies has been ascribed to local hemodynamic changes, whereby SGLT2 inhibition results in decreased sodium reabsorption with consequent increased sodium delivery to the macula densa, increased afferent arterial tone and decreased estimated glomerular filtration rate (GFR), indicative of reduced hyperfiltration [17, 21, 45, 46]. Here, SLC5A2 is linked to kidney disorder.