Claudin-1 has been reported to overexpress in colon cancer, in particular in metastatic cells with mislocalization from the cell membrane to the cell nucleus and cytoplasm, and regulate cellular transformation and metastasis in xenograft tumor model through its effects on E-cadherin and β-catenin/Tcf signaling [38]. Here, HNF4A is linked to malignant colon neoplasm.