GPT and Hepatic steatosis: In an animal model, HFD-fed LysMCre-RORαfl/fl illustrated a lower level of M2 markers in RORα-deficient KCs, and resulted in severe hepatic steatosis, increment in serum glutamic pyruvic transaminase (GPT) and glutamic oxaloacetate transaminase (GOT), and hepatocyte ballooning with lipid droplets.