In an animal model, HFD-fed LysMCre-RORαfl/fl illustrated a lower level of M2 markers in RORα-deficient KCs, and resulted in severe hepatic steatosis, increment in serum glutamic pyruvic transaminase (GPT) and glutamic oxaloacetate transaminase (GOT), and hepatocyte ballooning with lipid droplets. The gene discussed is GPT; the disease is fatty liver disease.