Focussing on our overall aim to establish a regenerative approach for AF closure, based on implantation of biomaterials supplemented with growth factors and/or cell recruiting factors like chemokines, the aim of our current study was to compare the effect of BMP2, -7, -12, -14, TGFβ3, which were found as a component in PRP [17], CCL25 and PRP-derived platelet lysate on the formation of extracellular AF matrix, in a 3D high-density cell culture assay. The gene discussed is BMP2; the disease is atrial fibrillation.