However, there was a significant decrease in co-localization of ORF3-FL with the ER and Golgi markers as compared to those from ORF3-Trnc in infected cells (PCC ± SD; ER: ORF3-FL = 0.12 ± 0.07, ORF3-Trnc = 0.46 ± 0.12 and Golgi: ORF3-FL = 0.27 ± 0.09, ORF3-Trnc = 0.65 ± 0.05, Figure S6), suggesting a distinct biological characteristics of the ORF3 variants during virus infection. The gene discussed is ASZ1; the disease is viral infectious disease.