TP53 and neoplasm: In this study, 25 distinct AAHs were discovered in the lung resection specimens derived from six different patients with invasive lung adenocarcinoma; the most frequently mutated genes were BRAF (16%) and ARID1A (16%); EGFR and MALM1 were mutated in three AAHs in two of the six patients; TP53 and KRAS were mutated in several AAHs within the same tumor; alterations in growth factors other than EGFR are observed in 28% of AAHs [31].