In a subsequent study the same authors have shown that EMT induction promotes the secretion of soluble factors by NSCLC acting in an autocrine way and promoting NF-kB activity, which in turn upregulates INHBA/Activin, a morphogen of the TGF-beta superfamily, responsible for the maintenance of the EMY phenotype and for the stimulation of cancer-initiating cell self-renewal [191]. This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.