The most significantly focally amplified genes in lung adenocarcinomas are NKX2-1, MYC, TERT, MCL1 and MDM2, while in LSQCC the most amplified were SOX2, CCND1, FGFR1, MYC, YES1, MIR205 and EGFR [43]. This evidence concerns the gene MDM2 and lung adenocarcinoma.