The comparative analysis of the transcriptome into the CD166+ and CD166− tumor cell populations showed the existence of some cancer stem cell-associated genes, such as the oncogenic stem cell factor LIN28B and the embryonic lung transcription factors PEA3 and NPAS1; this analysis showed also that the glycine/serine metabolism enzymes are highly enriched in CD166+ cells [174]. The gene discussed is LIN28B; the disease is cancer.