TP53 and lung cancer: Gene expression profiling studies showed a number of typical abnormalities in basaloid lung cancers, consisting in: (a) overexpression of genes related to TP53 mutation signature, transcription factors (such as SOX4, SOX9, SOX11 and MYB), methylation regulation (such as DNMT1 and DNMT3), cell cycle, survival (such as BCL2) and embryonic development (such as FGF3 and FGF9); (b) down-regulation of genes related to squamous cell differentiation, such as genes related to keratinocyte differentiation [84].