The combination of mutational and gene expression data allowed to identify several pathways that are affected in lung adenocarcinoma: genes involved in extracellular matrix interaction, focal and adhesion, cell-cycle and JAK-STAT (JAK2 is mutated in about 1% of NSCLCs) pathways are significantly enriched in lung adenocarcinomas [11]. This evidence concerns the gene SOAT1 and lung adenocarcinoma.