STK11 and lung adenocarcinoma: In fact, it was shown that LKB1 loss in lung adenocarcinoma activates YAP (a major effector of the Hippo pathway) which in turn upregulates ZEB2 expression and represses DNp63 transcription which inhibits squamous cell transdifferentiation; during transdifferentiation, YAP is inactivated, thus relieving the ZB2-mediated repression of DNp63 and thus inducing the program of squamous cell differentiation [254].