The tumor genomic landscape of tumors occurring in non-smokers and in smokers was recently compared and many remarkable differences have been reported: (a) mutation frequencies were higher in smokers than in never smokers tumor samples; (b) a different mutation spectrum in smokers (predominant C:G↣A:T) and never-smokers (C:G↣T:A) was observed; (c) distinctive sets of mutated genes in never-smokers (EGFR mutations and ALK and ROS1 fusions) and smokers (KRAS, TP53, BRAF, JAK2 and JAK3 and mismatch repair genes mutations). This evidence concerns the gene JAK2 and neoplasm.