Recently, Sun and coworkers reported the mutational spectrum of lung adenocarcinomas occurring in East Asian non-smoker patients and showed that in a very high proportion (about 80%) of these patients EGFR mutations ae involved; in another 10% of these patients either ELML-ALK fusions or HER2 insertions occur; finally, only 2% of these patients displayed KRAS mutations [16]. This evidence concerns the gene EGFR and lung adenocarcinoma.