In NSCLC the more frequently mutated genes with known potential function of driver genes are the following: EGFR (10−30%), FGFR1 (20%), KRAS (15−30%), PIK3CA (2−5%), ERBB2 (HER2) (2−5%), BRAF (1−3%), ALK (3%), ROS1 (1%), MAP2K1/MEK1 (1%), RET (1%), NRAS (1%) and AKT1 (<1%) (reviewed in [10]). The gene discussed is ERBB2; the disease is non-small cell lung carcinoma.