The overall survival observed in a large set of NSCLC patients treated with anti-PD-1 or PD-L1 inhibitors or with chemotherapy showed that for patients treated with immune check inhibitors, but not with chemotherapy, there is a good correlation with the LIPI index: 3 months, 10 months and 34 months of OS associated with a poor, intermediate and good LIPI, respectively [298]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.