RB1 and neoplasm: The results of this study confirmed that TP53 and RB1 were altered in almost all tumor with biallelic inactivation, sometimes related to complex genomic rearrangements; interestingly, two SCLCs with wild-type RB1 showed evidence of chromotripsis, leading to overexpression of Cyclin D1, thus indicating an alternative mechanism of RB1 deregulation [99].