Some genes significantly mutated were exclusively mutated in lung adenocarcinoma, such as STK11 (LKB1), RBM10, KEAP1, RIT1 and MET, while other genes such as NFE2L2, KDM6A, RASA1, NOTCH1 and HRAS are significantly mutated in LSQCC [43]. Here, NFE2L2 is linked to lung adenocarcinoma.