The most commonly mutated genes in in lung adenocarcinoma include KRAS and EGFR and the tumor suppressor genes TP53, KEAP1, STK11 and NF1. KRAS and EGFR mutations are usually mutually exclusive, but when they co-exist, KRAS mutations confer resistance to EGFR inhibitors. The gene discussed is KEAP1; the disease is lung adenocarcinoma.