TGFB1 and nasopharyngeal carcinoma: Although EBNA1 has been shown to suppress TGF-β-mediated transcription in AdAH and HL cells [95,100], in NPC cells, EBNA1 appeared to up-regulate the expression of TGF-β1 protein leading to a reduction in expression of miR-200a and miR-200b which in turn, up-regulated their target genes ZEB1 and ZEB2, well known mediators of EMT [149].