Further, it has been shown that LMP1 can down-regulate the expression of limb-bud and heart (LBH) resulting in the alleviation of TGF-β1-induced NF-kB signalling inhibition, rendering NPC cells refractory to TGF-β1-mediated cytostasis [93]. The gene discussed is PDLIM7; the disease is nasopharyngeal carcinoma.