Similarly, the expression of IL-6 was found decreased on colitis-induced Balb/c mice fed with F. vesiculosus fucoidan-enriched meals [85], while in a model of gastric ulceration, the oral administration of 20 mg/kg body weight of this polysaccharide to Wistar rats diminished the aspirin-induced up-regulation of plasma PGE2 and IL-6, and significantly increased the expression of the anti-inflammatory IL-10 [86]. Here, IL6 is linked to gastric ulcer.