In A549 lung carcinoma cells and Raji cells, F. vesiculosus fucoidan was found to suppress the expression of matrix metalloproteinase 2 and 9, respectively [103,104], while fucoidans from F. serratus, F. distichus, and F. vesiculosus were shown to block the formation of platelet-tumor aggregates, i.e., a mechanism of tumor cells transportation and fixation in the metastatic site, of a highly metastatic MDA-MB-231 breast cancer cells [96], thus preventing the tumor dissemination and metastization. Here, MMP2 is linked to neoplasm.