CRP and Brain atrophy: Some studies found indeed a positive correlation between higher C-reactive protein (CRP), IL-6 levels and sUA levels [19,48] and between inflammatory markers and white matter hyper-intensity (WMH, (p < 0.01)), lower gray matter (p = 0.001) and hippocampal (p = 0.01) volumes, that are indirect markers of brain atrophy, supporting the hypothesis of a strong connection between elevated sUA levels, inflammation, and VD [49].