With respect to cytokine production a knockout (k.o.)of ZIP14 in mice, a transporter important for the regulation of zinc homeostasis in hepatocytes, showed lower mRNA expression of TNF-α, IL-6, IL-1β, and IL-10 in the liver compared to wild-type (w.t.)mice after induction of sepsis in a murine model. This evidence concerns the gene TNF and Sepsis.