CD4 and adenocarcinoma: Kinoshita et al. focused on the relationship between TILs, histological type, and smoking habit, showing that a low number of CD8+ T cells in non-adenocarcinoma, a high FOXP3/CD4 ratio in smokers with adenocarcinoma, and a low number of CD20+ B cells in non-smokers with adenocarcinoma were identified as independent prognostic factors in resected NSCLC [43].